For research use only. Not for therapeutic Use.
SDZ 224-015（Cat No.:I045259）is a potent and selective inhibitor of leukotriene B4 (LTB4) receptors, blocking LTB4-mediated chemotaxis and activation of neutrophils. By antagonizing this pro-inflammatory lipid signaling pathway, SDZ 224-015 reduces leukocyte recruitment and inflammation in conditions driven by excessive LTB4 activity. It has been investigated in models of asthma, arthritis, and other chronic inflammatory diseases. With strong receptor affinity and favorable pharmacological properties, SDZ 224-015 is a valuable tool for studying leukotriene biology, immune cell trafficking, and the development of targeted anti-inflammatory therapies that modulate eicosanoid-mediated immune responses.
| CAS Number | 161511-45-1 |
| Synonyms | [(3S)-5-ethoxy-3-[[(2S)-2-[[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]propanoyl]amino]-2,5-dioxopentyl] 2,6-dichlorobenzoate |
| Molecular Formula | C30H35Cl2N3O9 |
| Purity | ≥95% |
| IUPAC Name | [(3S)-5-ethoxy-3-[[(2S)-2-[[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]propanoyl]amino]-2,5-dioxopentyl] 2,6-dichlorobenzoate |
| InChI | InChI=1S/C30H35Cl2N3O9/c1-5-42-24(37)14-22(23(36)16-43-29(40)25-20(31)12-9-13-21(25)32)34-27(38)18(4)33-28(39)26(17(2)3)35-30(41)44-15-19-10-7-6-8-11-19/h6-13,17-18,22,26H,5,14-16H2,1-4H3,(H,33,39)(H,34,38)(H,35,41)/t18-,22-,26-/m0/s1 |
| InChIKey | VMKPCENEHPIWJT-DOPYIHRPSA-N |
| SMILES | CCOC(=O)C[C@@H](C(=O)COC(=O)C1=C(C=CC=C1Cl)Cl)NC(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)OCC2=CC=CC=C2 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
