SCH-23390 hydrochloride

• CAT Number: R049211
• CAS Number: 125941-87-9
• Molecular Formula: C17H19Cl2NO
• Molecular Weight: 324.24
• Purity: ≥95%
• Synonyms: (5R)-8-chloro-3-methyl-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol;hydrochloride
• InChI: InChI=1S/C17H18ClNO.ClH/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12;/h2-6,9-10,15,20H,7-8,11H2,1H3;1H/t15-;/m1./s1
• InChIKey: OYCAEWMSOPMASE-XFULWGLBSA-N
• SMILES: CN1CCC2=CC(=C(C=C2C(C1)C3=CC=CC=C3)O)Cl.Cl

SCH-23390 hydrochloride (Cat No.: R049211) is a selective dopamine D1-like receptor antagonist with the molecular formula C17H18ClNO•HCl. It is widely used in neuroscience research to study dopaminergic signaling, motor control, and reward pathways. By blocking D1 receptors, SCH-23390 alters dopamine-mediated neurotransmission, helping researchers investigate conditions like Parkinson’s disease, schizophrenia, and addiction. The hydrochloride salt form enhances its solubility and stability for experimental use. SCH-23390 is known for its high potency and selectivity, making it a valuable pharmacological tool in behavioral and neurochemical studies.

Reference

[1]. Bourne JA, et al . SCH 23390: the first selective dopamine D1-like receptor antagonist. CNS Drug Rev. 2001 Winter;7(4):399-414.
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[2]. Millan MJ, et al. The “selective” dopamine D1 receptor antagonist, SCH23390, is a potent and high efficacy agonist at cloned human serotonin2C receptors. Psychopharmacology (Berl). 2001 Jun;156(1):58-62.
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[3]. Kuzhikandathil EV, et al. Classic D1 dopamine receptor antagonist R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (SCH23390) directly inhibits G protein-coupledinwardly rectifying potassium channels. Mol Pharmacol. 2002 Jul;62(1):119-26.
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[4]. Wang YH, et al. Isosibiricin inhibits microglial activation by targeting the dopamine D1/D2 receptor-dependent NLRP3/caspase-1 inflammasome pathway. Acta Pharmacol Sin. 2020 Feb;41(2):173-180.
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[5]. Crockett SL, et al. Role of dopamine and selective dopamine receptor agonists on mouse ductus arteriosus tone and responsiveness. Pediatr Res. 2019 Dec 9.
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