SBC-115337

• CAT Number: I045245
• CAS Number: 423148-46-3
• Molecular Formula: C29H19N3O4
• Molecular Weight: 473.48
• Purity: ≥95%
• Synonyms: N-[4-[[4-(1,3-benzoxazol-2-yl)phenyl]carbamoyl]phenyl]-1-benzofuran-2-carboxamide
• InChI: InChI=1S/C29H19N3O4/c33-27(30-21-15-11-19(12-16-21)29-32-23-6-2-4-8-25(23)36-29)18-9-13-22(14-10-18)31-28(34)26-17-20-5-1-3-7-24(20)35-26/h1-17H,(H,30,33)(H,31,34)
• InChIKey: ALQIZRCPSILFNQ-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)C=C(O2)C(=O)NC3=CC=C(C=C3)C(=O)NC4=CC=C(C=C4)C5=NC6=CC=CC=C6O5

SBC-115337（Cat No.:I045245）is a small-molecule inhibitor of the mitochondrial protease caseinolytic protease P (ClpP). By binding to ClpP’s active site, it disrupts proteolytic activity, impairing mitochondrial protein quality control and function. This inhibition induces mitochondrial stress, leading to apoptosis in cancer cells reliant on ClpP for survival. SBC-115337 has shown potential in preclinical oncology studies, particularly in targeting metabolic and proteostasis vulnerabilities in tumors. Its specificity and cell permeability make it a valuable research tool for dissecting ClpP’s role in mitochondrial biology and exploring novel anticancer therapeutic strategies involving mitochondrial protease inhibition.