For research use only. Not for therapeutic Use.
SB-657510(CAT: I010671) is a potent and selective urotensin II (UII) receptor (UT) antagonist with Ki values of 61, 17, 30, 65, and 56 nM for human, monkey, cat, rat, and mouse receptors, respectively. It exerts strong anti-inflammatory activity by blocking UII-induced upregulation of adhesion molecules, cytokines, and tissue factor in vascular endothelial cells. In vitro, SB-657510 inhibits UII-mediated cell adhesion and tissue factor expression, while in vivo it reduces ERK phosphorylation in diabetic mouse aortas. SB-657510 also suppresses high-fat diet–induced and diabetes-associated atherosclerosis, making it a valuable pharmacological tool for cardiovascular research and metabolic disease studies.
| CAS Number | 474960-44-6 |
| Synonyms | 2-bromo-N-[4-chloro-3-[(3R)-1-methylpyrrolidin-3-yl]oxyphenyl]-4,5-dimethoxybenzenesulfonamide |
| Molecular Formula | C19H22BrClN2O5S |
| Purity | ≥95% |
| IUPAC Name | 2-bromo-N-[4-chloro-3-[(3R)-1-methylpyrrolidin-3-yl]oxyphenyl]-4,5-dimethoxybenzenesulfonamide |
| InChI | InChI=1S/C19H22BrClN2O5S/c1-23-7-6-13(11-23)28-16-8-12(4-5-15(16)21)22-29(24,25)19-10-18(27-3)17(26-2)9-14(19)20/h4-5,8-10,13,22H,6-7,11H2,1-3H3/t13-/m1/s1 |
| InChIKey | KQCZCINJGIRLCD-CYBMUJFWSA-N |
| SMILES | CN1CCC(C1)OC2=C(C=CC(=C2)NS(=O)(=O)C3=C(C=C(C(=C3)OC)OC)Br)Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
