For research use only. Not for therapeutic Use.
SB-328437（Cat No.:I009333）is a selective antagonist of the CC chemokine receptor 3 (CCR3), a G protein-coupled receptor primarily expressed on eosinophils, basophils, and Th2 cells. By blocking CCR3, SB-328437 inhibits the binding and activity of eotaxins and other chemokines involved in eosinophil recruitment and activation. It is widely used in immunology and allergy research to study mechanisms underlying allergic inflammation, asthma, and eosinophil-mediated diseases. SB-328437 serves as a valuable pharmacological tool for exploring CCR3-targeted therapeutic strategies aimed at controlling allergic responses and chronic inflammatory conditions associated with eosinophilia.
| CAS Number | 247580-43-4 |
| Synonyms | methyl (2S)-2-(naphthalene-1-carbonylamino)-3-(4-nitrophenyl)propanoate |
| Molecular Formula | C21H18N2O5 |
| Purity | ≥95% |
| IUPAC Name | methyl (2S)-2-(naphthalene-1-carbonylamino)-3-(4-nitrophenyl)propanoate |
| InChI | InChI=1S/C21H18N2O5/c1-28-21(25)19(13-14-9-11-16(12-10-14)23(26)27)22-20(24)18-8-4-6-15-5-2-3-7-17(15)18/h2-12,19H,13H2,1H3,(H,22,24)/t19-/m0/s1 |
| InChIKey | VMFGCGRAIBLAFY-IBGZPJMESA-N |
| SMILES | COC(=O)[C@H](CC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)C2=CC=CC3=CC=CC=C32 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
