For research use only. Not for therapeutic Use.
SB-216763（Cat No.:I044025）is a potent and selective inhibitor of glycogen synthase kinase-3 (GSK-3), targeting both GSK-3α and GSK-3β isoforms. By inhibiting this serine/threonine kinase, SB-216763 modulates critical cellular processes including glycogen metabolism, cell proliferation, apoptosis, and inflammation. It has been widely used in research on neurodegenerative diseases, such as Alzheimer’s, as well as cancer, diabetes, and stem cell differentiation. SB-216763 mimics the effects of Wnt signaling activation, making it a valuable tool for studying developmental biology and regenerative medicine pathways, particularly through modulation of β-catenin-mediated transcription.
| CAS Number | 2756818-39-8 |
| Synonyms | 7-methoxy-4-(2-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-1,3-dihydroquinoxalin-2-one |
| Molecular Formula | C17H18N4O2 |
| Purity | ≥95% |
| IUPAC Name | 7-methoxy-4-(2-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-1,3-dihydroquinoxalin-2-one |
| InChI | InChI=1S/C17H18N4O2/c1-10-18-13-5-3-4-12(13)17(19-10)21-9-16(22)20-14-8-11(23-2)6-7-15(14)21/h6-8H,3-5,9H2,1-2H3,(H,20,22) |
| InChIKey | UEPKZTFWZFQXML-UHFFFAOYSA-N |
| SMILES | CC1=NC2=C(CCC2)C(=N1)N3CC(=O)NC4=C3C=CC(=C4)OC |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
