Saruparib

• CAT Number: I022878
• CAS Number: 2589531-76-8
• Molecular Formula: C22H26N6O2
• Molecular Weight: 406.48
• Purity: ≥95%
• Synonyms: 5-[4-[(7-ethyl-6-oxo-5H-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl]-N-methylpyridine-2-carboxamide
• InChI: InChI=1S/C22H26N6O2/c1-3-16-11-19-20(26-21(16)29)10-15(12-24-19)14-27-6-8-28(9-7-27)17-4-5-18(25-13-17)22(30)23-2/h4-5,10-13H,3,6-9,14H2,1-2H3,(H,23,30)(H,26,29)
• InChIKey: WQAVGRAETZEADU-UHFFFAOYSA-N
• SMILES: CCC1=CC2=C(C=C(C=N2)CN3CCN(CC3)C4=CN=C(C=C4)C(=O)NC)NC1=O

Saruparib (Cat No.: I022878) is a next-generation, highly selective PARP1 inhibitor developed to enhance antitumor efficacy while minimizing off-target effects. Unlike earlier dual PARP1/2 inhibitors, saruparib selectively targets PARP1, reducing hematologic toxicity. It is being evaluated in clinical trials for BRCA-mutated and HR-deficient cancers, including ovarian, breast, and prostate cancers. Saruparib enhances synthetic lethality in tumor cells with DNA repair defects and holds promise as both monotherapy and in combination with chemotherapy or targeted agents.

Reference

[1]. Illuzzi G, et, al. Preclinical Characterization of AZD5305, A Next-Generation, Highly Selective PARP1 Inhibitor and Trapper. Clin Cancer Res. 2022 Nov 1;28(21):4724-4736.
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[2]. Johannes JW, et, al. Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs. J Med Chem. 2021 Oct 14;64(19):14498-14512.
[Content Brief]