SAR502250（Cat No.:I044667）is a potent, selective, and orally bioavailable inhibitor of glycogen synthase kinase-3β (GSK-3β), a key enzyme involved in neurodegenerative diseases and mood disorders. With an IC₅₀ of approximately 12 nM, SAR502250 effectively crosses the blood-brain barrier and exhibits neuroprotective and antidepressant-like effects in preclinical models. It reduces tau hyperphosphorylation, improves cognitive performance in Alzheimer’s disease models, and protects neurons from amyloid-beta toxicity. SAR502250 is also active in behavioral models of anxiety and depression, making it a valuable research tool for studying GSK-3β-related signaling and developing therapies for neurological conditions.