Sappanone A

• CAT Number: I045590
• CAS Number: 102067-84-5
• Molecular Formula: C16H12O5
• Molecular Weight: 284.26
• Purity: ≥95%
• Synonyms: (3E)-3-[(3,4-dihydroxyphenyl)methylidene]-7-hydroxychromen-4-one
• InChI: InChI=1S/C16H12O5/c17-11-2-3-12-15(7-11)21-8-10(16(12)20)5-9-1-4-13(18)14(19)6-9/h1-7,17-19H,8H2/b10-5+
• InChIKey: KVYZXXBTJHJISR-BJMVGYQFSA-N
• SMILES: C1C(=CC2=CC(=C(C=C2)O)O)C(=O)C3=C(O1)C=C(C=C3)O

Sappanone A (Cat No.: I045590) is a homoisoflavanone isolated from the heartwood of Caesalpinia sappan (sappanwood), a plant traditionally used in Asian medicine. It exhibits a wide range of biological activities, including antioxidant, anti-inflammatory, antimicrobial, and anticancer effects. Sappanone A has been reported to inhibit pro-inflammatory mediators, modulate oxidative stress pathways, and suppress tumor cell proliferation. In research, it serves as a natural product probe for drug discovery and pharmacology studies, offering insights into the therapeutic potential of plant-derived flavonoids and homoisoflavonoids.

Reference

[1]. Lee S, et, al. Sappanone A exhibits anti-inflammatory effects via modulation of Nrf2 and NF-κB. Int Immunopharmacol. 2015 Sep;28(1):328-36.
[Content Brief]

[2]. Liu X, et, al. Sappanone A Attenuates Allergic Airway Inflammation in Ovalbumin-Induced Asthma. Int Arch Allergy Immunol. 2016;170(3):180-6.
[Content Brief]