For research use only. Not for therapeutic Use.
Samelisant (Cat No.: I009656) is a selective histamine H3 receptor inverse agonist developed for research in neurological and sleep-related disorders. By blocking presynaptic H3 autoreceptors, it enhances the release of histamine, acetylcholine, dopamine, and norepinephrine in the brain. This action promotes wakefulness and cognitive function, making Samelisant a valuable tool for studying sleep–wake regulation, attention deficits, and neurodegenerative conditions. It is being investigated as a potential therapy for narcolepsy, excessive daytime sleepiness, and related central nervous system disorders.
| CAS Number | 1394808-20-8 |
| Synonyms | N-[4-(1-cyclobutylpiperidin-4-yl)oxyphenyl]-2-morpholin-4-ylacetamide;dihydrochloride |
| Molecular Formula | C21H33Cl2N3O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C21H31N3O3.2ClH/c25-21(16-23-12-14-26-15-13-23)22-17-4-6-19(7-5-17)27-20-8-10-24(11-9-20)18-2-1-3-18;;/h4-7,18,20H,1-3,8-16H2,(H,22,25);2*1H |
| InChIKey | LCPQCTBHZPMVFX-UHFFFAOYSA-N |
| SMILES | C1CC(C1)N2CCC(CC2)OC3=CC=C(C=C3)NC(=O)CN4CCOCC4.Cl.Cl |
| Reference | [1]. Ramakrishna Nirogi, et al. Samelisant (SUVN-G3031), a potent, selective and orally active histamine H3 receptor inverse agonist for the potential treatment of narcolepsy: pharmacological and neurochemical characterisation. Psychopharmacology (Berl). 2021 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
