Salicylohydroxamic Acid

• CAT Number: R049501
• CAS Number: 89-73-6
• Molecular Formula: C7H7NO3
• Molecular Weight: 153.14
• Purity: ≥95%
• Synonyms: N,2-Dihydroxy-benzamide; 2-Hydroxybenzenehydroxamic Acid; 2-Hydroxybenzohydroxamic Acid; 2-Hydroxyphenylhydroxamic Acid; N,2-Dihydroxybenzamide; NSC 193440; NSC 5088
• Storage: -20°C
• IUPAC Name: N,2-dihydroxybenzamide
• InChI: InChI=1S/C7H7NO3/c9-6-4-2-1-3-5(6)7(10)8-11/h1-4,9,11H,(H,8,10)
• InChIKey: HBROZNQEVUILML-UHFFFAOYSA-N
• SMILES: C1=CC=C(C(=C1)C(=O)NO)O

Salicylohydroxamic acid (CAT: R049501) is an aromatic hydroxamic acid derivative (C₇H₇NO₃) containing both hydroxamic acid and ortho-hydroxy functional groups on a benzene ring. It is best known as a potent inhibitor of urease, an enzyme that hydrolyzes urea into ammonia and carbon dioxide. By chelating the nickel ions in the urease active site, SHA effectively blocks enzymatic activity, making it valuable in agricultural research for reducing ammonia volatilization from urea-based fertilizers and in medical studies targeting urease-producing pathogens such as Helicobacter pylori. Its metal-binding properties also make it useful in coordination chemistry and bioinorganic research.