For research use only. Not for therapeutic Use.
SAHM1 (Cat No.:I044302) is a synthetic peptide designed to inhibit the NOTCH signaling pathway by mimicking a segment of the Mastermind-like 1 (MAML1) protein. It disrupts the formation of the NOTCH transcriptional activation complex (NOTCH/CSL/MAML), thereby blocking downstream gene transcription involved in cell proliferation and survival. SAHM1 is particularly significant in cancer research, especially in targeting NOTCH-dependent tumors such as T-cell acute lymphoblastic leukemia (T-ALL). Its stabilized alpha-helical structure enhances cellular uptake and proteolytic resistance, making it a valuable tool for therapeutic and mechanistic studies.
| CAS Number | 2050906-89-1 |
| Molecular Formula | C94H162N36O23S |
| Purity | ≥95% |
| IUPAC Name | (4S)-4-[[(2S)-2-acetamidopropanoyl]amino]-5-[[(2S)-5-carbamimidamido-1-[[(2S)-1-[[(2S)-5-carbamimidamido-1-[[(2S)-5-carbamimidamido-1-[[(2S)-5-carbamimidamido-1-[[(2S,3S)-1-[[(3S,6R,9S,12S,16Z,21S)-3-(3-carbamimidamidopropyl)-21-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(1S,2R)-1-carboxy-2-hydroxypropyl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]carbamoyl]-12,21-dimethyl-9-(2-methylpropyl)-2,5,8,11-tetraoxo-6-(sulfanylmethyl)-1,4,7,10-tetrazacyclohenicos-16-en-12-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-5-oxopentanoic acid |
| InChI | InChI=1S/C94H162N36O23S/c1-12-50(6)69(127-76(141)59(27-22-36-110-91(101)102)118-72(137)56(24-19-33-107-88(95)96)116-73(138)57(25-20-34-108-89(97)98)119-77(142)62(38-48(2)3)121-74(139)58(26-21-35-109-90(99)100)117-75(140)61(29-30-68(134)135)115-71(136)51(7)114-53(9)133)84(149)130-94(11)32-18-16-14-13-15-17-31-93(10,129-83(148)60(28-23-37-111-92(103)104)120-82(147)67(45-154)124-78(143)63(39-49(4)5)125-87(94)153)86(152)126-65(41-55-43-106-47-113-55)80(145)122-64(40-54-42-105-46-112-54)79(144)123-66(44-131)81(146)128-70(52(8)132)85(150)151/h13-14,42-43,46-52,56-67,69-70,131-132,154H,12,15-41,44-45H2,1-11H3,(H,105,112)(H,106,113)(H,114,133)(H,115,136)(H,116,138)(H,117,140)(H,118,137)(H,119,142)(H,120,147)(H,121,139)(H,122,145)(H,123,144)(H,124,143)(H,125,153)(H,126,152)(H,127,141)(H,128,146)(H,129,148)(H,130,149)(H,134,135)(H,150,151)(H4,95,96,107)(H4,97,98,108)(H4,99,100,109)(H4,101,102,110)(H4,103,104,111)/b14-13-/t50-,51-,52+,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,69-,70-,93-,94-/m0/s1 |
| InChIKey | ADWKVIAAKDSBNE-VHQDTIAVSA-N |
| SMILES | CC[C@H](C)[C@@H](C(=O)N[C@]1(CCC/C=C\CCC[C@@](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CC(C)C)CS)CCCNC(=N)N)(C)C(=O)N[C@@H](CC2=CNC=N2)C(=O)N[C@@H](CC3=CNC=N3)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)O)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
