For research use only. Not for therapeutic Use.
Safimaltib (Cat No.:I044413) is a selective, orally bioavailable inhibitor of RAF kinases, including BRAF and CRAF, with potential antitumor activity. It targets the MAPK/ERK signaling pathway, which is frequently dysregulated in cancers driven by BRAF mutations, such as melanoma and colorectal cancer. Safimaltib binds to RAF kinases and inhibits their activity, suppressing downstream MEK and ERK phosphorylation, leading to reduced cell proliferation and tumor growth. It is used in preclinical and clinical research to explore targeted therapies for RAF-dependent malignancies and resistance mechanisms.
| CAS Number | 2230273-76-2 |
| Synonyms | 1-(1-oxo-2H-isoquinolin-5-yl)-5-(trifluoromethyl)-N-[2-(trifluoromethyl)pyridin-4-yl]pyrazole-4-carboxamide |
| Molecular Formula | C20H11F6N5O2 |
| Purity | ≥95% |
| IUPAC Name | 1-(1-oxo-2H-isoquinolin-5-yl)-5-(trifluoromethyl)-N-[2-(trifluoromethyl)pyridin-4-yl]pyrazole-4-carboxamide |
| InChI | InChI=1S/C20H11F6N5O2/c21-19(22,23)15-8-10(4-6-27-15)30-18(33)13-9-29-31(16(13)20(24,25)26)14-3-1-2-12-11(14)5-7-28-17(12)32/h1-9H,(H,28,32)(H,27,30,33) |
| InChIKey | APWRZPQBPCAXFP-UHFFFAOYSA-N |
| SMILES | C1=CC2=C(C=CNC2=O)C(=C1)N3C(=C(C=N3)C(=O)NC4=CC(=NC=C4)C(F)(F)F)C(F)(F)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
