S65487 sulfate

• CAT Number: I044575
• CAS Number: 2416937-01-2
• Molecular Formula: C41H43ClN6O8S
• Molecular Weight: 815.33
• Purity: ≥95%
• Synonyms: 5-[5-chloro-2-[(3S)-3-(morpholin-4-ylmethyl)-3,4-dihydro-1H-isoquinoline-2-carbonyl]phenyl]-N-(5-cyano-1,2-dimethylpyrrol-3-yl)-N-(4-hydroxyphenyl)-1,2-dimethylpyrrole-3-carboxamide;sulfuric acid
• InChI: InChI=1S/C41H41ClN6O4.H2O4S/c1-26-36(41(51)48(31-10-12-34(49)13-11-31)38-21-32(23-43)44(3)27(38)2)22-39(45(26)4)37-20-30(42)9-14-35(37)40(50)47-24-29-8-6-5-7-28(29)19-33(47)25-46-15-17-52-18-16-46;1-5(2,3)4/h5-14,20-22,33,49H,15-19,24-25H2,1-4H3;(H2,1,2,3,4)/t33-;/m0./s1
• InChIKey: ZLAZYXMNPRHARH-WAQYZQTGSA-N
• SMILES: CC1=C(C=C(N1C)C2=C(C=CC(=C2)Cl)C(=O)N3CC4=CC=CC=C4C[C@H]3CN5CCOCC5)C(=O)N(C6=CC=C(C=C6)O)C7=C(N(C(=C7)C#N)C)C.OS(=O)(=O)O

S65487 sulfate（Cat No.:I044575）is a potent, selective inhibitor of the anti-apoptotic protein BCL-2, designed to induce programmed cell death in cancer cells. By binding with high affinity to BCL-2 and sparing BCL-XL, S65487 sulfate minimizes the risk of thrombocytopenia while promoting apoptosis, particularly in hematologic malignancies like chronic lymphocytic leukemia and acute myeloid leukemia. It demonstrates strong efficacy in preclinical models with favorable pharmacodynamic properties and safety profile. S65487 sulfate is a valuable research tool for studying BCL-2-mediated survival pathways and for developing targeted therapies against resistant cancer types.