For research use only. Not for therapeutic Use.
S65487（Cat No.:I044576）is a highly selective BCL-2 inhibitor developed to trigger apoptosis in cancer cells by disrupting BCL-2/BAX interactions. Unlike earlier compounds, it shows minimal activity against BCL-XL, reducing the risk of thrombocytopenia. S65487 exhibits potent pro-apoptotic activity, particularly in hematologic cancers such as chronic lymphocytic leukemia and acute myeloid leukemia. It demonstrates strong efficacy in preclinical models with favorable safety and pharmacokinetic profiles. By targeting BCL-2, a key regulator of cell survival, S65487 serves as a promising therapeutic agent and a powerful tool for apoptosis and cancer biology research.
| CAS Number | 1644600-79-2 |
| Synonyms | 5-[5-chloro-2-[(3S)-3-(morpholin-4-ylmethyl)-3,4-dihydro-1H-isoquinoline-2-carbonyl]phenyl]-N-(5-cyano-1,2-dimethylpyrrol-3-yl)-N-(4-hydroxyphenyl)-1,2-dimethylpyrrole-3-carboxamide |
| Molecular Formula | C41H41ClN6O4 |
| Purity | ≥95% |
| IUPAC Name | 5-[5-chloro-2-[(3S)-3-(morpholin-4-ylmethyl)-3,4-dihydro-1H-isoquinoline-2-carbonyl]phenyl]-N-(5-cyano-1,2-dimethylpyrrol-3-yl)-N-(4-hydroxyphenyl)-1,2-dimethylpyrrole-3-carboxamide |
| InChI | InChI=1S/C41H41ClN6O4/c1-26-36(41(51)48(31-10-12-34(49)13-11-31)38-21-32(23-43)44(3)27(38)2)22-39(45(26)4)37-20-30(42)9-14-35(37)40(50)47-24-29-8-6-5-7-28(29)19-33(47)25-46-15-17-52-18-16-46/h5-14,20-22,33,49H,15-19,24-25H2,1-4H3/t33-/m0/s1 |
| InChIKey | VNNWQLOUMFCVJD-XIFFEERXSA-N |
| SMILES | CC1=C(C=C(N1C)C2=C(C=CC(=C2)Cl)C(=O)N3CC4=CC=CC=C4C[C@H]3CN5CCOCC5)C(=O)N(C6=CC=C(C=C6)O)C7=C(N(C(=C7)C#N)C)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
