S65487 hydrochloride

• CAT Number: I044574
• CAS Number: 1644543-95-2
• Molecular Formula: C41H42Cl2N6O4
• Molecular Weight: 753.72
• Purity: ≥95%
• Synonyms: 5-[5-chloro-2-[(3S)-3-(morpholin-4-ylmethyl)-3,4-dihydro-1H-isoquinoline-2-carbonyl]phenyl]-N-(5-cyano-1,2-dimethylpyrrol-3-yl)-N-(4-hydroxyphenyl)-1,2-dimethylpyrrole-3-carboxamide;hydrochloride
• InChI: InChI=1S/C41H41ClN6O4.ClH/c1-26-36(41(51)48(31-10-12-34(49)13-11-31)38-21-32(23-43)44(3)27(38)2)22-39(45(26)4)37-20-30(42)9-14-35(37)40(50)47-24-29-8-6-5-7-28(29)19-33(47)25-46-15-17-52-18-16-46;/h5-14,20-22,33,49H,15-19,24-25H2,1-4H3;1H/t33-;/m0./s1
• InChIKey: KBXPYZATHHDCAQ-WAQYZQTGSA-N
• SMILES: CC1=C(C=C(N1C)C2=C(C=CC(=C2)Cl)C(=O)N3CC4=CC=CC=C4C[C@H]3CN5CCOCC5)C(=O)N(C6=CC=C(C=C6)O)C7=C(N(C(=C7)C#N)C)C.Cl

S65487 hydrochloride（Cat No.:I044574）is a selective, potent BCL-2 inhibitor that promotes apoptosis in cancer cells by disrupting the BCL-2/BAX interaction. It exhibits high affinity for BCL-2 with minimal activity against BCL-XL, reducing thrombocytopenia risk—a limitation of earlier BCL-2 inhibitors. S65487 hydrochloride effectively induces cell death in hematologic malignancies such as acute myeloid leukemia and chronic lymphocytic leukemia. Preclinical studies demonstrate robust antitumor activity, favorable pharmacokinetics, and a strong therapeutic index. This compound is a promising candidate for targeted cancer therapy and mechanistic studies of apoptotic regulation.