For research use only. Not for therapeutic Use.
S516（Cat No.:I017737）is a potent, selective inhibitor of dynamin-related protein 1 (Drp1), a GTPase crucial for mitochondrial fission. By blocking Drp1 activity, S516 disrupts excessive mitochondrial fragmentation, promoting mitochondrial integrity and function. This compound is widely used to study mitochondrial dynamics, apoptosis, and energy metabolism. Its role in modulating mitochondrial morphology makes it valuable in research on neurodegenerative diseases, cardiovascular disorders, and cancer, where abnormal fission contributes to pathology. S516 provides a powerful pharmacological tool for exploring therapeutic strategies targeting mitochondrial homeostasis and cellular health.
| CAS Number | 1016543-77-3 |
| Synonyms | [4-(2-amino-1,3-thiazol-4-yl)-2-(1,2,4-triazol-1-yl)phenyl]-(3,4,5-trimethoxyphenyl)methanone |
| Molecular Formula | C21H19N5O4S |
| Purity | ≥95% |
| IUPAC Name | [4-(2-amino-1,3-thiazol-4-yl)-2-(1,2,4-triazol-1-yl)phenyl]-(3,4,5-trimethoxyphenyl)methanone |
| InChI | InChI=1S/C21H19N5O4S/c1-28-17-7-13(8-18(29-2)20(17)30-3)19(27)14-5-4-12(15-9-31-21(22)25-15)6-16(14)26-11-23-10-24-26/h4-11H,1-3H3,(H2,22,25) |
| InChIKey | OJZSPKKXYGZDRQ-UHFFFAOYSA-N |
| SMILES | COC1=CC(=CC(=C1OC)OC)C(=O)C2=C(C=C(C=C2)C3=CSC(=N3)N)N4C=NC=N4 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
