S3QEL-2

• CAT Number: R032757
• CAS Number: 890888-12-7
• Molecular Formula: C19H25N5
• Molecular Weight: 323.44
• Purity: ≥95%
• Synonyms: 1-(3,4-dimethylphenyl)-N,N-dipropylpyrazolo[3,4-d]pyrimidin-4-amine
• InChI: InChI=1S/C19H25N5/c1-5-9-23(10-6-2)18-17-12-22-24(19(17)21-13-20-18)16-8-7-14(3)15(4)11-16/h7-8,11-13H,5-6,9-10H2,1-4H3
• InChIKey: MGIAJZSCNPODRR-UHFFFAOYSA-N
• SMILES: CCCN(CCC)C1=NC=NC2=C1C=NN2C3=CC(=C(C=C3)C)C

S3QEL-2 (Cat No.: R032757) is a selective small-molecule inhibitor that suppresses superoxide production at site IIIQ of mitochondrial complex III without impairing oxidative phosphorylation. By specifically reducing reactive oxygen species (ROS) generation, it allows researchers to study the role of mitochondrial redox signaling in health and disease. S3QEL-2 is applied in investigations of oxidative stress, aging, inflammation, and metabolic disorders. Its unique selectivity distinguishes it from general antioxidants, making it a valuable research tool for dissecting mitochondrial ROS contributions to pathology.

Reference

[1]. Orr AL, et al. Suppressors of superoxide production from mitochondrial complex III. Nat Chem Biol. 2015;11(11):834-836.
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