For research use only. Not for therapeutic Use.
S2157（Cat No.:I015183）is a potent and selective inhibitor of casein kinase 1 (CK1), a serine/threonine kinase involved in regulating circadian rhythm, Wnt/β-catenin signaling, DNA damage response, and cell cycle progression. By suppressing CK1 activity, S2157 provides a valuable tool to dissect kinase-mediated pathways implicated in cancer, neurodegenerative diseases, and inflammatory disorders. Preclinical studies indicate that CK1 inhibition can modulate tumor growth and sensitize cells to therapeutic agents. S2157 is widely applied in molecular biology, pharmacology, and biomedical research as a chemical probe.
| CAS Number | 2262488-39-9 |
| Molecular Formula | C23H28ClF2N3O2 |
| Purity | ≥95% |
| IUPAC Name | 2-[[(1R,2S)-2-(3,5-difluoro-2-phenylmethoxyphenyl)cyclopropyl]amino]-1-(4-methylpiperazin-1-yl)ethanone;hydrochloride |
| InChI | InChI=1S/C23H27F2N3O2.ClH/c1-27-7-9-28(10-8-27)22(29)14-26-21-13-18(21)19-11-17(24)12-20(25)23(19)30-15-16-5-3-2-4-6-16;/h2-6,11-12,18,21,26H,7-10,13-15H2,1H3;1H/t18-,21+;/m0./s1 |
| InChIKey | PUXYOFXCUCMFSQ-OZYANKIXSA-N |
| SMILES | CN1CCN(CC1)C(=O)CN[C@@H]2C[C@H]2C3=C(C(=CC(=C3)F)F)OCC4=CC=CC=C4.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
