(S)-(-)-Indoline-2-carboxylic acid

• CAT Number: M003752
• CAS Number: 79815-20-6
• Molecular Formula: C9H9NO2
• Molecular Weight: 163.18
• Purity: ≥95%
• Synonyms: (R)-1H-INDOLE-2-CARBOXYLIC ACID;(R)-2,3-DIHYDRO-1H-INDOLE-2-CARBOXYLIC ACID;(R)-(+)-2,3-DIHYDROINDOLE-2-CARBOXYLIC ACID;Perindopril Intermediate;(2S)-indoline-2-carboxylic acid;(2S)-2,3-dihydro-1H-Indole-2-carboxylic acid;(S)-(-)-Indoline-2-Carboxyli
• Storage: -20°C
• IUPAC Name: (2S)-2,3-dihydro-1H-indole-2-carboxylic acid
• InChI: InChI=1S/C9H9NO2/c11-9(12)8-5-6-3-1-2-4-7(6)10-8/h1-4,8,10H,5H2,(H,11,12)/t8-/m0/s1
• InChIKey: QNRXNRGSOJZINA-QMMMGPOBSA-N
• SMILES: C1C(NC2=CC=CC=C21)C(=O)O

(S)-(-)-Indoline-2-carboxylic acid (Cat No.: M003752) is a chiral, heterocyclic compound featuring an indoline core with a carboxylic acid group at the 2-position in the (S)-enantiomeric configuration. It is used as a valuable building block in asymmetric synthesis, pharmaceuticals, and peptidomimetics, where stereochemistry is crucial for biological activity. The compound contributes rigidity and chirality to molecular frameworks, enhancing binding specificity and stability. Its applications include drug design, synthesis of bioactive molecules, and structure-activity relationship (SAR) studies in medicinal and synthetic organic chemistry.

Reference

1.Kunz, Roxanne K., and David WC MacMillan. "Enantioselective organocatalytic cyclopropanations. The identification of a new class of iminium catalyst based upon directed electrostatic activation." Journal of the American Chemical Society 127.10 (2005): 3240-3241.