For research use only. Not for therapeutic Use.
(S)-ErSO (Cat No.: I045396) is a stereoisomer of ErSO, a small-molecule activator of the estrogen receptor (ER) stress response pathway, specifically designed to target ER-positive breast cancer cells. It rapidly induces a unique form of cellular stress called anticipatory unfolded protein response (a-UPR), leading to selective tumor cell death while sparing normal tissues. (S)-ErSO shows potent antitumor activity in preclinical models, including those resistant to standard endocrine therapies. It is under investigation as a promising therapeutic agent for aggressive, treatment-resistant ER-positive breast cancers.
| CAS Number | 2407860-34-6 |
| Synonyms | (3S)-3-(4-hydroxyphenyl)-3-[4-(trifluoromethoxy)phenyl]-7-(trifluoromethyl)-1H-indol-2-one |
| Molecular Formula | C22H13F6NO3 |
| Purity | ≥95% |
| InChI | InChI=1S/C22H13F6NO3/c23-21(24,25)17-3-1-2-16-18(17)29-19(31)20(16,12-4-8-14(30)9-5-12)13-6-10-15(11-7-13)32-22(26,27)28/h1-11,30H,(H,29,31)/t20-/m0/s1 |
| InChIKey | ZFSRXAHDJSCEDS-FQEVSTJZSA-N |
| SMILES | C1=CC2=C(C(=C1)C(F)(F)F)NC(=O)C2(C3=CC=C(C=C3)O)C4=CC=C(C=C4)OC(F)(F)F |
| Reference | [1]. David J. Shapiro, et al. Activators of the unfolded protein response. WO2020009958A1. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
