S-acetyl-PEG4-propargyl

• CAT Number: I016479
• CAS Number: 1422540-88-2
• Molecular Formula: C13H22O5S
• Molecular Weight: 290.38
• Purity: ≥95%
• Synonyms: S-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethyl] ethanethioate
• InChI: InChI=1S/C13H22O5S/c1-3-4-15-5-6-16-7-8-17-9-10-18-11-12-19-13(2)14/h1H,4-12H2,2H3
• InChIKey: IOVXBDYSVBLUMS-UHFFFAOYSA-N
• SMILES: CC(=O)SCCOCCOCCOCCOCC#C

S-acetyl-PEG4-propargyl(CAT: I016479) is a heterobifunctional linker featuring an S-acetyl-protected thiol and a terminal alkyne group connected by a PEG4 spacer. Upon mild deprotection, the thiol can be selectively conjugated to maleimides or other thiol-reactive groups, while the alkyne enables click chemistry (CuAAC or SPAAC) with azide-functionalized molecules. The PEG4 chain improves aqueous solubility, molecular flexibility, and reduces steric hindrance, ensuring efficient coupling. This reagent is widely used in bioconjugation, probe development, antibody–drug conjugates (ADCs), and materials science. S-acetyl-PEG4-propargyl provides a versatile platform for constructing multifunctional biomolecules, redox-sensitive linkages, and advanced nanomaterials for chemical biology and drug delivery.