For research use only. Not for therapeutic Use.
S-777469（Cat No.:I035899）is a selective cannabinoid receptor type 2 (CB2) agonist developed for the treatment of inflammatory and pruritic skin disorders, such as atopic dermatitis. By activating CB2 receptors, which are primarily expressed in immune cells and peripheral tissues, S-777469 modulates immune responses and reduces the release of pro-inflammatory cytokines and histamine. Unlike CB1 agonists, it lacks psychoactive effects due to minimal central nervous system activity. S-777469 has demonstrated efficacy in preclinical and clinical models by alleviating itch and inflammation, making it a promising candidate for non-steroidal dermatological therapy.
| CAS Number | 885496-53-7 |
| Synonyms | 1-[[6-ethyl-1-[(4-fluorophenyl)methyl]-5-methyl-2-oxopyridine-3-carbonyl]amino]cyclohexane-1-carboxylic acid |
| Molecular Formula | C23H27FN2O4 |
| Purity | ≥95% |
| IUPAC Name | 1-[[6-ethyl-1-[(4-fluorophenyl)methyl]-5-methyl-2-oxopyridine-3-carbonyl]amino]cyclohexane-1-carboxylic acid |
| InChI | InChI=1S/C23H27FN2O4/c1-3-19-15(2)13-18(20(27)25-23(22(29)30)11-5-4-6-12-23)21(28)26(19)14-16-7-9-17(24)10-8-16/h7-10,13H,3-6,11-12,14H2,1-2H3,(H,25,27)(H,29,30) |
| InChIKey | JIYXOJFSPOFZPY-UHFFFAOYSA-N |
| SMILES | CCC1=C(C=C(C(=O)N1CC2=CC=C(C=C2)F)C(=O)NC3(CCCCC3)C(=O)O)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
