(S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-(trifluoromethyl)phenyl)propanoic acid

• CAT Number: L046341
• CAS Number: 507472-19-7
• Molecular Formula: C25H20F3NO4
• Molecular Weight: 455.40
• Purity: ≥95%
• IUPAC Name: (3S)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[2-(trifluoromethyl)phenyl]propanoic acid
• InChI: InChI=1S/C25H20F3NO4/c26-25(27,28)21-12-6-5-11-19(21)22(13-23(30)31)29-24(32)33-14-20-17-9-3-1-7-15(17)16-8-2-4-10-18(16)20/h1-12,20,22H,13-14H2,(H,29,32)(H,30,31)/t22-/m0/s1
• InChIKey: WUSGYGWDKAFPBR-QFIPXVFZSA-N
• SMILES: C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)N[C@@H](CC(=O)O)C4=CC=CC=C4C(F)(F)F

(S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-(trifluoromethyl)phenyl)propanoic acid（Cat No.:L046341）is a chiral, Fmoc-protected α-amino acid derivative used primarily in solid-phase peptide synthesis (SPPS). The (S)-configuration ensures enantiomeric purity, crucial for synthesizing bioactive peptides. The Fmoc group protects the amine functionality, allowing for stepwise chain elongation under mild basic conditions. The presence of a trifluoromethyl-substituted aromatic side chain imparts unique physicochemical properties, such as enhanced hydrophobicity and metabolic stability. This compound is valuable in the development of peptides and peptidomimetics, especially when fluorinated residues are desired for modulating biological activity or pharmacokinetics.