S-22153

• CAT Number: I009254
• CAS Number: 180304-07-8
• Molecular Formula: C14H17NOS
• Molecular Weight: 247.36
• Purity: ≥95%
• Synonyms: N-[2-(5-ethyl-1-benzothiophen-3-yl)ethyl]acetamide
• InChI: InChI=1S/C14H17NOS/c1-3-11-4-5-14-13(8-11)12(9-17-14)6-7-15-10(2)16/h4-5,8-9H,3,6-7H2,1-2H3,(H,15,16)
• InChIKey: PICRXJDULXLJCZ-UHFFFAOYSA-N
• SMILES: CCC1=CC2=C(C=C1)SC=C2CCNC(=O)C

S-22153 (Cat No.: I009254) is a potent and selective antagonist of the melatonin MT1 and MT2 receptors, both of which regulate circadian rhythms and sleep–wake cycles. By blocking melatonin signaling, S-22153 has been used to investigate the physiological roles of melatonin in neuroendocrine regulation, sleep biology, and mood disorders. Its activity provides insights into receptor-mediated chronobiology and the therapeutic potential of targeting melatonin receptors. S-22153 is a valuable pharmacological tool for studying circadian rhythm modulation and melatonin-dependent pathways in neuroscience research.

Reference

[1]. Li XM, et al. Circadian rhythm entrainment with melatonin, melatonin receptor antagonist S22153 or their combination in mice exposed to constant light. J Pineal Res. 2004;37(3):176-184.
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[2]. Audinot V, et al. New selective ligands of human cloned melatonin MT1 and MT2 receptors. Naunyn Schmiedebergs Arch Pharmacol. 2003;367(6):553-561.
[Content Brief]