For research use only. Not for therapeutic Use.
S 18986(CAT: I009253) is a selective, orally active, and brain-penetrant positive allosteric modulator of AMPA-type glutamate receptors with robust cognitive-enhancing properties in rodents. It facilitates neurotransmitter release, including noradrenaline and acetylcholine in the hippocampus, and improves memory performance in object-recognition and spatial learning models. S 18986 demonstrates particularly strong anti-amnesic effects in middle-aged animals compared to aged ones, supporting its role in age-related cognitive decline research. Intraperitoneal administration (5–50 mg/kg) enhances both the induction and maintenance of tetanus-evoked long-term potentiation, highlighting its utility in studying synaptic plasticity, learning, memory, and neurodegenerative disease mechanisms.
| CAS Number | 175340-20-2 |
| Synonyms | (3aS)-2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine 5,5-dioxide |
| Molecular Formula | C10H12N2O2S |
| Purity | ≥95% |
| IUPAC Name | (3aS)-2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine 5,5-dioxide |
| InChI | InChI=1S/C10H12N2O2S/c13-15(14)9-5-2-1-4-8(9)12-7-3-6-10(12)11-15/h1-2,4-5,10-11H,3,6-7H2/t10-/m1/s1 |
| InChIKey | MNTIJYGEITVWHU-SNVBAGLBSA-N |
| SMILES | C1CC2NS(=O)(=O)C3=CC=CC=C3N2C1 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
