(S)-1-(2-Amino-5-chlorophenyl)-1-(trifluoromethyl)-3-cyclopropyl-2-propyn-1-ol

• CAT Number: R059337
• CAS Number: 209414-27-7
• Molecular Formula: C13H11ClF3NO
• Molecular Weight: 289.68
• Purity: ≥95%
• Synonyms: (S)-2-(2-Amino-5-chlorophenyl)-4-cyclopropyl-1,1,1-trifluoro-3-butyn-2-ol; (αS)-2-Amino-5-chloro-α-(2-cyclopropylethynyl)-α-(trifluoromethyl)benzenemethanol; USP Efavirenz Related Compound A
• Storage: RT
• IUPAC Name: (2S)-2-(2-amino-5-chlorophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol
• InChI: InChI=1S/C13H11ClF3NO/c14-9-3-4-11(18)10(7-9)12(19,13(15,16)17)6-5-8-1-2-8/h3-4,7-8,19H,1-2,18H2/t12-/m0/s1
• InChIKey: KEMUGFRERPPUHB-LBPRGKRZSA-N
• SMILES: C1CC1C#C[C@](C2=C(C=CC(=C2)Cl)N)(C(F)(F)F)O

(S)-1-(2-Amino-5-chlorophenyl)-1-(trifluoromethyl)-3-cyclopropyl-2-propyn-1-ol（Cat No.:R059337）is a chiral, fluorinated alkyne-containing compound with applications in pharmaceutical research and development. Featuring a substituted phenyl ring with amino and chloro groups, a trifluoromethyl moiety, a cyclopropyl ring, and a propargylic alcohol structure, it offers multiple reactive and stereochemically defined sites. The (S)-enantiomer configuration is crucial for its activity in target-specific interactions, particularly in enzyme or receptor modulation. This molecule is of interest in medicinal chemistry for designing kinase inhibitors, antiviral agents, or CNS-active drugs due to its balance of rigidity, lipophilicity, and polar functional groups.