RU 58841 (Cat.No:I001957) is a nonsteroidal antiandrogen drug. It has been studied for its potential application in the treatment of androgenic alopecia, a common form of hair loss. RU 58841 works by binding to androgen receptors, blocking the effects of dihydrotestosterone (DHT) on hair follicles, and promoting hair growth.
| Catalog Number | I001957 |
| CAS Number | 154992-24-2 |
| Synonyms | 4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile |
| Molecular Formula | C17H18F3N3O3 |
| Purity | 95% |
| Target | Androgen Receptor |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| IUPAC Name | 4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile |
| InChI | InChI=1S/C17H18F3N3O3/c1-16(2)14(25)23(15(26)22(16)7-3-4-8-24)12-6-5-11(10-21)13(9-12)17(18,19)20/h5-6,9,24H,3-4,7-8H2,1-2H3 |
| InChIKey | ARBYGDBJECGMGA-UHFFFAOYSA-N |
| SMILES | N#CC1=CC=C(N(C(N(CCCCO)C2(C)C)=O)C2=O)C=C1C(F)(F)F |
| Reference | </br>1:RU 58841-myristate–prodrug development for topical treatment of acne and androgenetic alopecia. Münster U, Nakamura C, Haberland A, Jores K, Mehnert W, Rummel S, Schaller M, Korting HC, Zouboulis ChC, Blume-Peytavi U, Schäfer-Korting M.Pharmazie. 2005 Jan;60(1):8-12. PMID: 15700772 </br>2:Local inhibition of sebaceous gland growth by topically applied RU 58841. Matias JR, Gaillard M.Ann N Y Acad Sci. 1995 Jun 12;761:56-65. PMID: 7625751 </br>3:RU 58841, a new specific topical antiandrogen: a candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism. Battmann T, Bonfils A, Branche C, Humbert J, Goubet F, Teutsch G, Philibert D.J Steroid Biochem Mol Biol. 1994 Jan;48(1):55-60. PMID: 8136306 |
