(R,S,S)-VH032

• CAT Number: I040627
• CAS Number: 2230826-33-0
• Molecular Formula: C22H30N4O3S
• Molecular Weight: 430.56
• Purity: ≥95%
• Synonyms: (2R,4S)-1-[(2S)-2-amino-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
• InChI: InChI=1S/C22H30N4O3S/c1-13-18(30-12-25-13)15-7-5-14(6-8-15)10-24-20(28)17-9-16(27)11-26(17)21(29)19(23)22(2,3)4/h5-8,12,16-17,19,27H,9-11,23H2,1-4H3,(H,24,28)/t16-,17+,19+/m0/s1
• InChIKey: ZLOXMSNKPDWMEF-YQVWRLOYSA-N
• SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)N)O

(R,S,S)-VH032(CAT: I040627) is a stereochemically defined ligand used in the development of PROTACs (proteolysis-targeting chimeras) for targeted protein degradation. This compound functions as a high-affinity ligand for the von Hippel-Lindau (VHL) E3 ubiquitin ligase complex, facilitating the recruitment of VHL to target proteins for ubiquitination and subsequent proteasomal degradation. The (R,S,S) stereochemistry of VH032 is critical for maintaining selective and potent binding to VHL. It is widely used in chemical biology and drug discovery to design bifunctional molecules aimed at degrading disease-relevant proteins.