RS 09

• CAT Number: P000319
• CAS Number: 1449566-36-2
• Molecular Formula: C31H49N9O9
• Molecular Weight: 691.78
• Purity: ≥95%
• Synonyms: (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-1-[(2S)-2-aminopropanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoic acid
• InChI: InChI=1S/C31H49N9O9/c1-16(2)11-20(27(44)38-22(14-41)31(48)49)36-25(42)18(4)35-26(43)21(12-19-13-33-15-34-19)37-28(45)23-7-5-9-39(23)30(47)24-8-6-10-40(24)29(46)17(3)32/h13,15-18,20-24,41H,5-12,14,32H2,1-4H3,(H,33,34)(H,35,43)(H,36,42)(H,37,45)(H,38,44)(H,48,49)/t17-,18-,20-,21-,22-,23-,24-/m0/s1
• InChIKey: SHYNPSTXGFDOBD-HRALPVODSA-N
• SMILES: C[C@@H](C(=O)N1CCC[C@H]1C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CN=CN3)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)O)N

RS 09（Cat No.:P000319）is a synthetic lipopeptide and potent agonist of Toll-like receptor 4 (TLR4), developed as a safer and more effective alternative to bacterial lipopolysaccharide (LPS) for immune stimulation. By activating TLR4 signaling, it triggers innate immune responses, including NF-κB activation, cytokine release, and dendritic cell maturation, thereby enhancing adaptive immunity. RS 09 is widely used in immunology and vaccine research to study TLR4-mediated pathways, host–pathogen interactions, and adjuvant development. Its well-defined structure and reduced toxicity make it a reliable tool for probing innate immune activation mechanisms.