RRD-251

• CAT Number: I035726
• CAS Number: 72214-67-6
• Molecular Formula: C8H9Cl3N2S
• Molecular Weight: 271.59
• Purity: ≥95%
• Synonyms: (2,4-dichlorophenyl)methyl carbamimidothioate;hydrochloride
• InChI: InChI=1S/C8H8Cl2N2S.ClH/c9-6-2-1-5(7(10)3-6)4-13-8(11)12;/h1-3H,4H2,(H3,11,12);1H
• InChIKey: COMNQRICZGJVLE-UHFFFAOYSA-N
• SMILES: C1=CC(=C(C=C1Cl)Cl)CSC(=N)N.Cl

RRD-251 (Cat No.: I035726) is a selective small-molecule inhibitor that disrupts the interaction between Raf-1 kinase and the retinoblastoma protein (Rb). By blocking the Raf-1–Rb complex, RRD-251 prevents Rb phosphorylation, thereby restoring its tumor suppressor function and inhibiting cell cycle progression. This compound has demonstrated potent antiproliferative and pro-apoptotic effects in various cancer models, including lung, pancreatic, and melanoma. RRD-251 is widely used in oncology research to study cell cycle regulation, Raf signaling pathways, and therapeutic targeting of protein–protein interactions.

Reference

[1]. Sandeep Singh, et al. Rb-Raf-1 interaction disruptor RRD-251 induces apoptosis in metastatic melanoma cells and synergizes with dacarbazine. Mol Cancer Ther. 2010 Dec; 9(12): 3330–3341.
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