Rotundifuran

• CAT Number: I035702
• CAS Number: 50656-65-0
• Molecular Formula: C22H34O4
• Molecular Weight: 362.50
• Purity: ≥95%
• Synonyms: [(1R,3R,4R,4aS,8aS)-4-[2-(furan-3-yl)ethyl]-4-hydroxy-3,4a,8,8-tetramethyl-2,3,5,6,7,8a-hexahydro-1H-naphthalen-1-yl] acetate
• InChI: InChI=1S/C22H34O4/c1-15-13-18(26-16(2)23)19-20(3,4)9-6-10-21(19,5)22(15,24)11-7-17-8-12-25-14-17/h8,12,14-15,18-19,24H,6-7,9-11,13H2,1-5H3/t15-,18-,19+,21+,22-/m1/s1
• InChIKey: QKHCQFQIJKXMOE-UGFIEOPBSA-N
• SMILES: CC1CC(C2C(CCCC2(C1(CCC3=COC=C3)O)C)(C)C)OC(=O)C

Rotundifuran (Cat No.: I035702) is a naturally occurring diterpenoid furan isolated from plants such as Vitex trifolia and Vitex rotundifolia. It exhibits diverse pharmacological properties, including anticancer, anti-inflammatory, antioxidant, and neuroprotective activities. Rotundifuran has been shown to induce apoptosis in various cancer cell lines by modulating mitochondrial pathways and caspase activation. Additionally, it reduces oxidative stress and inflammatory mediator production, supporting its therapeutic potential. As a bioactive natural compound, Rotundifuran serves as a valuable tool in phytochemistry, pharmacology, and drug discovery.

Reference

[1]. Ko WG, et, al. Rotundifuran, a labdane type diterpene from Vitex rotundifolia, induces apoptosis in human myeloid leukaemia cells. Phytother Res. 2001 Sep; 15(6):535-7.
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[2]. Li WX, et, al. Labdane-type diterpenes as new cell cycle inhibitors and apoptosis inducers from Vitex trifolia L. J Asian Nat Prod Res. 2005 Apr; 7(2): 95-105.
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