Rotigotine Hydrochloride

• CAT Number: I001020
• CAS Number: 125572-93-2
• Molecular Formula: C19H26ClNOS
• Molecular Weight: 351.93
• Purity: ≥95%
• Synonyms: (6S)-6-[propyl(2-thiophen-2-ylethyl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol;hydrochloride
• Target: 5-HT Receptor
• Solubility: 10 mM in water ; 100 mM in DMSO
• Storage: Store at -20°C
• IC50: 13/0.71 nM (D2/D3) [1]

Rotigotine Hcl is dopamine D2 and D3 receptor agonist. Ki values are 13 and 0.71 nM for D2 and D3 respectively.IC50 value: 13/0.71 nM (D2/D3) [1]Target: D2 and D3 receptorRotigotine also has significant affinity for 5-HT1A and adrenergic α2B receptors. Rotigotine exhibits antiparkinsonian acitivity.

Reference

[1]. Belluzzi et al (2004) N-0923, a selective dopamine D2 receptor agonist, is efficacious in rat and monkey models of Parkinson/’s disease. Mov.disord. 9 147.