For research use only. Not for therapeutic Use.
RORγt Inverse Agonist 3（Cat No.:I018995）is a potent small-molecule modulator targeting the retinoic acid receptor-related orphan receptor gamma t (RORγt), a nuclear receptor that regulates Th17 cell differentiation and interleukin-17 (IL-17) expression. By acting as an inverse agonist, it reduces RORγt activity, thereby suppressing pro-inflammatory cytokine production. This compound is widely used in immunology research to explore mechanisms underlying autoimmune diseases such as psoriasis, rheumatoid arthritis, and multiple sclerosis. RORγt Inverse Agonist 3 provides a valuable tool for studying transcriptional regulation and therapeutic development in inflammation and autoimmunity.
| CAS Number | 2364429-77-4 |
| Synonyms | (2S)-1-[2,4-dichloro-3-[[4-(3-methylimidazol-4-yl)-2-propan-2-ylquinolin-8-yl]oxymethyl]phenyl]sulfonyl-N-methylpyrrolidine-2-carboxamide |
| Molecular Formula | C29H31Cl2N5O4S |
| Purity | ≥95% |
| IUPAC Name | (2S)-1-[2,4-dichloro-3-[[4-(3-methylimidazol-4-yl)-2-propan-2-ylquinolin-8-yl]oxymethyl]phenyl]sulfonyl-N-methylpyrrolidine-2-carboxamide |
| InChI | InChI=1S/C29H31Cl2N5O4S/c1-17(2)22-13-19(24-14-33-16-35(24)4)18-7-5-9-25(28(18)34-22)40-15-20-21(30)10-11-26(27(20)31)41(38,39)36-12-6-8-23(36)29(37)32-3/h5,7,9-11,13-14,16-17,23H,6,8,12,15H2,1-4H3,(H,32,37)/t23-/m0/s1 |
| InChIKey | LQMIVDIAZXZEPL-QHCPKHFHSA-N |
| SMILES | CC(C)C1=NC2=C(C=CC=C2OCC3=C(C=CC(=C3Cl)S(=O)(=O)N4CCC[C@H]4C(=O)NC)Cl)C(=C1)C5=CN=CN5C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
