Ropivacaine hydrochloride

• CAT Number: R064885
• CAS Number: 98717-15-8
• Molecular Formula: C17H27ClN2O
• Molecular Weight: 310.86
• Purity: ≥95%
• Synonyms: (2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide;hydrochloride
• InChI: InChI=1S/C17H26N2O.ClH/c1-4-11-19-12-6-5-10-15(19)17(20)18-16-13(2)8-7-9-14(16)3;/h7-9,15H,4-6,10-12H2,1-3H3,(H,18,20);1H/t15-;/m0./s1
• InChIKey: NDNSIBYYUOEUSV-RSAXXLAASA-N
• SMILES: CCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C.Cl

Ropivacaine Hydrochloride (Cat No.: R064885) is a long-acting local anesthetic used for surgical anesthesia, epidural blocks, and postoperative pain management. It works by blocking sodium channels in nerve cells, inhibiting nerve impulse transmission and producing reversible loss of sensation. Ropivacaine provides effective pain relief with less motor blockade and reduced cardiotoxicity compared to bupivacaine. Administered via injection, it is commonly used in obstetrics and orthopedic procedures. Side effects may include hypotension, bradycardia, dizziness, or, rarely, central nervous system or cardiovascular toxicity.

Reference

[1]. Dene Simpson, et al. Ropivacaine: a review of its use in regional anaesthesia and acute pain management. Drugs. 2005;65(18):2675-717.
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[2]. Li TF, et al. Epidural sustained release ropivacaine prolongs anti-allodynia and anti-hyperalgesia in developing and established neuropathic pain. PLoS One. 2015 Jan 24;10(1):e0117321.
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[3]. Hye Won Shin, et al. The inhibitory effects of bupivacaine, levobupivacaine, and ropivacaine on K2P (two-pore domain potassium) channel TREK-1. J Anesth. 2014 Feb;28(1):81-6.
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[4]. Milan Patel, et al. Ropivacaine Inhibits Pressure-Induced Lung Endothelial Hyperpermeability in Models of Acute Hypertension. Life Sci. 2019 Apr 1;222:22-28.
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