Ro60-0175

• CAT Number: I045501
• CAS Number: 169675-08-5
• Molecular Formula: C11H12ClFN2
• Molecular Weight: 226.68
• Purity: ≥95%
• Synonyms: (2S)-1-(6-chloro-5-fluoroindol-1-yl)propan-2-amine
• InChI: InChI=1S/C11H12ClFN2/c1-7(14)6-15-3-2-8-4-10(13)9(12)5-11(8)15/h2-5,7H,6,14H2,1H3/t7-/m0/s1
• InChIKey: XJJZQXUGLLXTHO-ZETCQYMHSA-N
• SMILES: CC(CN1C=CC2=CC(=C(C=C21)Cl)F)N

Ro60-0175 (Cat No.: I045501) is a potent and selective agonist of the serotonin 5-HT₂C receptor, a G protein–coupled receptor involved in regulating appetite, mood, and reward pathways. By activating 5-HT₂C receptors, Ro60-0175 modulates neurotransmitter release, particularly dopamine, in brain regions linked to feeding behavior and addiction. It has been studied for potential therapeutic applications in obesity, substance use disorders, and psychiatric conditions. Ro60-0175 is widely used in neuropharmacology to investigate 5-HT₂C receptor signaling, receptor selectivity, and the behavioral effects of serotonergic modulation in vivo.

Reference

[1]. Fletcher PJ, et al. The 5-HT2C receptor agonist Ro60-0175 reduces cocaine self-administration and reinstatement induced by the stressor yohimbine, and contextual cues. Neuropsychopharmacology. 2008;33(6):1402-1412.
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