For research use only. Not for therapeutic Use.
Ro 5212773 (Cat No.: R024326) is a selective inverse agonist of the histamine H3 receptor, a presynaptic receptor that regulates the release of histamine and other neurotransmitters. By blocking H3 receptor activity, Ro 5212773 enhances histaminergic signaling and modulates pathways involved in cognition, sleep-wake regulation, and attention. Researchers use it to investigate therapeutic approaches for neurological disorders such as narcolepsy, Alzheimer’s disease, and ADHD. Although not advanced for clinical application, Ro 5212773 serves as a valuable pharmacological probe in neuropharmacology and cognitive research.
| CAS Number | 1110781-88-8 |
| Synonyms | N-(3-ethoxyphenyl)-4-pyrrolidin-1-yl-3-(trifluoromethyl)benzamide |
| Molecular Formula | C20H21F3N2O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C20H21F3N2O2/c1-2-27-16-7-5-6-15(13-16)24-19(26)14-8-9-18(25-10-3-4-11-25)17(12-14)20(21,22)23/h5-9,12-13H,2-4,10-11H2,1H3,(H,24,26) |
| InChIKey | KLFVWQCQUXXLOU-UHFFFAOYSA-N |
| SMILES | CCOC1=CC=CC(=C1)NC(=O)C2=CC(=C(C=C2)N3CCCC3)C(F)(F)F |
| Reference | [1]. Bradaia A, et al. The selective antagonist EPPTB reveals TAAR1-mediated regulatory mechanisms in dopaminergic neurons of the mesolimbic system. Proc Natl Acad Sci U S A. 2009;106(47):20081-20086. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
