Ro 363 hydrochloride

• CAT Number: I045504
• CAS Number: 250580-70-2
• Molecular Formula: C19H26ClNO6
• Molecular Weight: 399.87
• Purity: ≥95%
• Synonyms: 4-[3-[2-(3,4-dimethoxyphenyl)ethylamino]-2-hydroxypropoxy]benzene-1,2-diol;hydrochloride
• InChI: InChI=1S/C19H25NO6.ClH/c1-24-18-6-3-13(9-19(18)25-2)7-8-20-11-14(21)12-26-15-4-5-16(22)17(23)10-15;/h3-6,9-10,14,20-23H,7-8,11-12H2,1-2H3;1H
• InChIKey: OGVPZFCVECYADQ-UHFFFAOYSA-N
• SMILES: COC1=C(C=C(C=C1)CCNCC(COC2=CC(=C(C=C2)O)O)O)OC.Cl

Ro 363 hydrochloride (Cat No.: I045504) is a synthetic glucocorticoid receptor (GR) agonist that modulates gene expression by binding to intracellular GRs, leading to anti-inflammatory and immunosuppressive effects. It is used in pharmacological research to study glucocorticoid-mediated signaling, receptor selectivity, and transcriptional regulation. The hydrochloride salt enhances solubility and stability for in vitro and in vivo applications. Ro 363 hydrochloride serves as a tool for exploring GR-related pathways, assessing anti-inflammatory drug mechanisms, and developing selective glucocorticoid receptor modulators with reduced side effects.

Reference

[1]. Maccarrone C, et al. Comparison of the Arrhythmogenic Actions of (-)-Isoprenaline, Dobutamine and the selective beta 1-adrenoceptor agonist, (+/-)-(1-[3′,4′-dihydroxyphenoxy] -2-hydroxy-[3″,4″-dimethoxy phenethylamino]-propane)-oxalate (Ro 363). Arzneimit
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[2]. Iakovidis D, et al. In vitro activity of RO363, a beta1-adrenoceptor selective agonist. Br J Pharmacol. 1980 Apr;68(4):677-85.
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[3]. Einstein R, et al. Comparison of the cardiac effects of beta-adrenoreceptor agonists in anaesthetised and conscious dogs. J Auton Pharmacol. 1986 Mar;6(1):9-14.
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