RNF5 inhibitor inh-02

• CAT Number: I035641
• CAS Number: 324579-65-9
• Molecular Formula: C23H20N4S
• Molecular Weight: 384.50
• Purity: ≥95%
• Synonyms: N-(4-benzyl-3-methyl-1,2,4-thiadiazol-5-ylidene)-N’-phenylbenzenecarboximidamide
• IUPAC Name: N-(4-benzyl-3-methyl-1,2,4-thiadiazol-5-ylidene)-N'-phenylbenzenecarboximidamide
• InChI: InChI=1S/C23H20N4S/c1-18-26-28-23(27(18)17-19-11-5-2-6-12-19)25-22(20-13-7-3-8-14-20)24-21-15-9-4-10-16-21/h2-16H,17H2,1H3
• InChIKey: FYZFQLYZABRFAZ-UHFFFAOYSA-N
• SMILES: CC1=NSC(=NC(=NC2=CC=CC=C2)C3=CC=CC=C3)N1CC4=CC=CC=C4

INH-02（Cat No.:I035641）is a small-molecule inhibitor targeting RNF5, an E3 ubiquitin ligase involved in protein homeostasis, ER-associated degradation (ERAD), and cellular stress responses. By inhibiting RNF5, INH-02 disrupts the degradation of key regulatory proteins, leading to enhanced autophagy and modulation of immune responses. It has shown anticancer potential, particularly by sensitizing tumor cells to immune-mediated killing and promoting immunogenic cell death. INH-02 is a promising tool for studying ubiquitin-proteasome system dynamics and offers therapeutic potential in oncology and inflammatory diseases where RNF5 activity contributes to disease progression.