RMC-4998

• CAT Number: I040768
• CAS Number: 2642037-07-6
• Molecular Formula: C57H74N8O7
• Molecular Weight: 983.25
• Purity: ≥95%
• Synonyms: (2S)-2-[(5S)-7-[4-(dimethylamino)-4-methylpent-2-ynoyl]-1-oxo-2,7-diazaspiro[4.4]nonan-2-yl]-N-[(8S,14S)-22-ethyl-21-[2-[(1S)-1-methoxyethyl]pyridin-3-yl]-18,18-dimethyl-9,15-dioxo-16-oxa-10,22,28-triazapentacyclo[18.5.2.12,6.110,14.023,27]nonacosa-1(26),2,4,6(29),20,23(27),24-heptaen-8-yl]-3-methylbutanamide
• InChI: InChI=1S/C57H74N8O7/c1-12-63-46-21-20-40-32-42(46)43(50(63)41-18-14-26-58-48(41)37(4)71-11)33-55(5,6)35-72-53(69)44-19-15-27-65(60-44)52(68)45(31-38-16-13-17-39(40)30-38)59-51(67)49(36(2)3)64-29-25-57(54(64)70)24-28-62(34-57)47(66)22-23-56(7,8)61(9)10/h13-14,16-18,20-21,26,30,32,36-37,44-45,49,60H,12,15,19,24-25,27-29,31,33-35H2,1-11H3,(H,59,67)/t37-,44-,45-,49-,57-/m0/s1
• InChIKey: VYZILERTWJIGRC-DOESOIHZSA-N
• SMILES: CCN1C2=C3C=C(C=C2)C4=CC=CC(=C4)CC(C(=O)N5CCCC(N5)C(=O)OCC(CC3=C1C6=C(N=CC=C6)C(C)OC)(C)C)NC(=O)C(C(C)C)N7CCC8(C7=O)CCN(C8)C(=O)C#CC(C)(C)N(C)C

RMC-4998(CAT: I040768) is a novel molecular glue compound with potent antitumor activity, specifically targeting KRAS G12C mutant cancers. It functions by promoting the formation of a ternary complex between cyclophilin A (CYPA) and the activated KRAS G12C mutant. This induced interaction blocks KRAS G12C from engaging with downstream effector proteins, thereby disrupting oncogenic signaling pathways that drive cell proliferation and tumor growth. RMC-4998 represents a unique therapeutic approach in targeting previously “undruggable” KRAS mutants and offers a powerful tool for precision oncology research, particularly in non-small cell lung cancer (NSCLC) and other KRAS-driven malignancies.