RKI-1447 dihydrochloride

• CAT Number: I045880
• CAS Number: 1782109-09-4
• Molecular Formula: C16H16Cl2N4O2S
• Molecular Weight: 399.29
• Purity: ≥95%
• Synonyms: 1-[(3-hydroxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea;dihydrochloride
• InChI: InChI=1S/C16H14N4O2S.2ClH/c21-13-3-1-2-11(8-13)9-18-15(22)20-16-19-14(10-23-16)12-4-6-17-7-5-12;;/h1-8,10,21H,9H2,(H2,18,19,20,22);2*1H
• InChIKey: GBXLRAPHQIRDNS-UHFFFAOYSA-N
• SMILES: C1=CC(=CC(=C1)O)CNC(=O)NC2=NC(=CS2)C3=CC=NC=C3.Cl.Cl

RKI-1447 dihydrochloride（Cat No.:I045880）is a potent and selective inhibitor of Rho-associated coiled-coil containing protein kinases (ROCK1 and ROCK2), key regulators of cytoskeletal organization, cell motility, and proliferation. By blocking ROCK activity, it disrupts actin-myosin contraction, stress fiber formation, and focal adhesion dynamics. This compound is widely applied in cancer research, fibrosis studies, and cardiovascular disease models, where aberrant ROCK signaling contributes to pathological progression. Supplied as a dihydrochloride salt for stability and solubility, RKI-1447 serves as a valuable tool for investigating ROCK-dependent cellular processes and therapeutic development.