RITA(CAT: I002641) stands for Reversal of Inhibitor of Transcription Activator. RITA is a small molecule that has been studied for its potential anti-cancer properties. It has been shown to induce apoptosis (programmed cell death) in cancer cells, inhibit tumor growth, and sensitize cancer cells to chemotherapy.
| Catalog Number | I002641 |
| CAS Number | 213261-59-7 |
| Synonyms | [5-[5-[5-(hydroxymethyl)thiophen-2-yl]furan-2-yl]thiophen-2-yl]methanol |
| Molecular Formula | C14H12O3S2 |
| Purity | 95% |
| Target | p53 |
| Solubility | DMSO 58mg/mL; Water <1 mg/mL; Ethanol 8 mg/mL |
| Storage | 3 years -20C powder |
| IC50 | 54nM in MCF-7 cells [4] |
| InChI | InChI=1S/C14H12O3S2/c15-7-9-1-5-13(18-9)11-3-4-12(17-11)14-6-2-10(8-16)19-14/h1-6,15-16H,7-8H2 |
| InChIKey | KZENBFUSKMWCJF-UHFFFAOYSA-N |
| SMILES | OCc1ccc(s1)c1ccc(o1)c1ccc(CO)s1 |
| Reference | </br>1:Structure-function analysis of RBPJ-interacting and tubulin-associated (RITA) reveals regions critical for repression of Notch target genes. Tabaja N, Yuan Z, Oswald F, Kovall RA.J Biol Chem. 2017 May 9. pii: jbc.M117.791707. doi: 10.1074/jbc.M117.791707. [Epub ahead of print] PMID: 28487372 Free Article</br>2:Ablation of Key Oncogenic Pathways by RITA-Reactivated p53 Is Required for Efficient Apoptosis. Grinkevich VV, Nikulenkov F, Shi Y, Enge M, Bao W, Maljukova A, Gluch A, Kel A, Sangfelt O, Selivanova G.Cancer Cell. 2017 May 8;31(5):724-726. doi: 10.1016/j.ccell.2017.04.014. No abstract available. PMID: 28486110 </br>3:Rita Phiroz Anklesaria. Kapadia R.BMJ. 2017 Apr 28;357:j2019. doi: 10.1136/bmj.j2019. No abstract available. PMID: 28455418 </br>4:RITA Mimics: Synthesis and Mechanistic Evaluation of Asymmetric Linked Trithiazoles. Pietkiewicz AL, Zhang Y, Rahimi MN, Stramandinoli M, Teusner M, McAlpine SR.ACS Med Chem Lett. 2017 Mar 6;8(4):401-406. doi: 10.1021/acsmedchemlett.6b00488. eCollection 2017 Apr 13. PMID: 28435526 </br>5:RITA displays anti-tumor activity in medulloblastomas independent of TP53 status. Gottlieb A, Althoff K, Grunewald L, Thor T, Odersky A, Schulte M, Deubzer HE, Heukamp L, Eggert A, Schramm A, Schulte JH, Künkele A.Oncotarget. 2017 Apr 25;8(17):27882-27891. doi: 10.18632/oncotarget.15840. PMID: 28427187 Free Article</br>6:Assessing the Relationship Between Mental Distress and Tobacco Use in Post-Katrina and Rita Louisiana. Mukherjee S, Canterberry M, Yore JB, Ledford EC, Carton TW.Subst Use Misuse. 2017 Mar 27:1-8. doi: 10.1080/10826084.2016.1273956. [Epub ahead of print] PMID: 28346036 </br>7:Reactivating p53 and Inducing Tumor Apoptosis (RITA) Enhances the Response of RITA-Sensitive Colorectal Cancer Cells to Chemotherapeutic Agents 5-Fluorouracil and Oxaliplatin. Wiegering A, Matthes N, Mühling B, Koospal M, Quenzer A, Peter S, Germer CT, Linnebacher M, Otto C.Neoplasia. 2017 Apr;19(4):301-309. doi: 10.1016/j.neo.2017.01.007. Epub 2017 Mar 9. PMID: 28284059 Free PMC Article</br>8:[Rita induce acute lymphoblostic leukemia cell apoptosis by activating P53 pathway]. Luo ZY, Jiang H, Xu L, Zhang XH.Zhonghua Xue Ye Xue Za Zhi. 2017 Feb 14;38(2):160-163. doi: 10.3760/cma.j.issn.0253-2727.2017.02.015. Chinese. No abstract available. PMID: 28279043 </br>9:[RITA combined with temozolomide inhibits the proliferation of human glioblastoma U87 cells]. He XY, Feng XL, Song XP, Zeng HC, Cao ZX, Xiao WW, Zhang B, Wu QH.Nan Fang Yi Ke Da Xue Xue Bao. 2016 Oct 20;36(10):1423-1428. Chinese. PMID: 27777210 </br>10:Targeting NF-κB RelA/p65 phosphorylation overcomes RITA resistance. Bu Y, Cai G, Shen Y, Huang C, Zeng X, Cao Y, Cai C, Wang Y, Huang D, Liao DF, Cao D.Cancer Lett. 2016 Dec 28;383(2):261-271. doi: 10.1016/j.canlet.2016.10.006. Epub 2016 Oct 6. PMID: 27721021 |
