Risperidone

• CAT Number: A000396
• CAS Number: 106266-06-2
• Molecular Formula: C23H27FN4O2
• Molecular Weight: 410.48
• Purity: ≥95%
• Synonyms: 3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one
• InChI: InChI=1S/C23H27FN4O2/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22/h5-6,14,16H,2-4,7-13H2,1H3
• InChIKey: RAPZEAPATHNIPO-UHFFFAOYSA-N
• SMILES: CC1=C(C(=O)N2CCCCC2=N1)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F

Risperidone (Cat No.: A000396) is an atypical antipsychotic used to treat schizophrenia, bipolar disorder, and irritability associated with autism. It works by antagonizing dopamine D2 and serotonin 5-HT2A receptors, helping to balance neurotransmitter activity in the brain. Risperidone is available in oral and long-acting injectable forms. Common side effects include weight gain, drowsiness, and extrapyramidal symptoms. It may increase prolactin levels and carries a risk of metabolic disturbances. Caution is advised in elderly patients with dementia-related psychosis due to increased mortality.

Reference

[1]. Nyberg S, et al. 5-HT2 and D2 dopamine receptor occupancy in the living human brain. A PET study with risperidone. Psychopharmacology (Berl). 1993;110(3):265-72.
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[2]. Chen ML, et al. Risperidone modulates the cytokine and chemokine release of dendritic cells and induces TNF-α-directed cell apoptosis in neutrophils. Int Immunopharmacol. 2012 Jan;12(1):197-204.
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[3]. Zhu HJ, et al. Risperidone and paliperidone inhibit p-glycoprotein activity in vitro. Neuropsychopharmacology. 2007 Apr;32(4):757-64.
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[4]. Bardgett ME, et al. Adult rats treated with risperidone during development are hyperactive. Exp Clin Psychopharmacol. 2013 Jun;21(3):259-67.
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