RIPK1-IN-4 (Cat No.:I018276) is a potent type II kinase receptor-interacting protein 1 (RIP1) kinase inhibitor and binds to the DL1-out inactive form of RIP1, for RIP1 and ADP- Glo kinase with IC50 of 16 nM and 10 nM, respectively. If you need, please contact us in time, and we will reply as soon as possible within 24 hours.
| Catalog Number | I018276 |
| CAS Number | 1481641-08-0 |
| Molecular Formula | C₂₃H₂₃N₅O₂ |
| Purity | 95% |
| Storage | Store at -20°C |
| IUPAC Name | 1-[4-(1-aminoisoquinolin-5-yl)phenyl]-3-(5-tert-butyl-1,2-oxazol-3-yl)urea |
| InChI | InChI=1S/C23H23N5O2/c1-23(2,3)19-13-20(28-30-19)27-22(29)26-15-9-7-14(8-10-15)16-5-4-6-18-17(16)11-12-25-21(18)24/h4-13H,1-3H3,(H2,24,25)(H2,26,27,28,29) |
| InChIKey | SLRYMOUSQMDJPH-UHFFFAOYSA-N |
| SMILES | CC(C)(C)C1=CC(=NO1)NC(=O)NC2=CC=C(C=C2)C3=CC=CC4=C3C=CN=C4N |
| Reference | [1]. Harris PA, et al. Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis. ACS Med Chem Lett. 2013 Nov 4;4(12):1238-43. |
