Ripasudil monohydrochloride dihydrate - CAS 887375-67-9

Ripasudil(cas 887375-67-9) is an inhibitor of Rho-associated protein kinase (ROCK; IC50s = 51 and 19 nM for ROCK-I and ROCK-II, respectively). Formulations containing ripasudil are used to lower intraocular pressure in the context of glaucoma and ocular hypertension.

Catalog Number: A000100

CAS Number: 887375-67-9

PubChem Substance ID:355038118

Molecular Formula: C15H18FN3O2S • HCl [2H2O]

Molecular Weight:395.9

Purity: ≥95%

* For research use only. Not for human or veterinary use.

Synonym

• Synonyms: Isoquinoline, 4-​fluoro-​5-​[[(2S)​-​hexahydro-​2-​methyl-​1H-​1,​4-​diazepin-​1-​yl]​sulfonyl]​-​, hydrochloride, hydrate (1:1:2)

Property

• Molecular Formula: C15H18FN3O2S • HCl [2H2O]
• Molecular Weight: 395.9
• Target: Rho
• Solubility: Soluble in DMSO
• Purity: ≥95%
• Storage: Store at -20°C

Computed Descriptor

• InChIKey: CMDJNMACGABCKQ-XVSRHIFFSA-N
• SMILES: FC1=C2C(C=CC=C2S(N3CCCNC[C@@H]3C)(=O)=O)=CN=C1.Cl.O.O