For research use only. Not for therapeutic Use.
RIDR-PI-103（Cat No.:I044031）is a dual inhibitor targeting both class I phosphoinositide 3-kinases (PI3Ks) and DNA-dependent protein kinase (DNA-PK), key regulators of cell survival, proliferation, and DNA damage response. By simultaneously blocking PI3K and DNA-PK activity, RIDR-PI-103 disrupts oncogenic signaling and impairs DNA repair mechanisms, enhancing sensitivity to genotoxic stress. This compound is particularly valuable in cancer research, especially for studying tumor resistance to radiotherapy and chemotherapy. RIDR-PI-103 offers a strategic approach to explore the therapeutic potential of dual pathway inhibition in malignancies reliant on PI3K signaling and efficient DNA repair.
| CAS Number | 2581114-71-6 |
| Synonyms | 2-amino-N-[5-amino-2-[3-(6-morpholin-4-yl-8-oxa-3,5,10-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-4-yl)phenoxy]phenyl]acetamide |
| Molecular Formula | C27H25N7O4 |
| Purity | ≥95% |
| IUPAC Name | 2-amino-N-[5-amino-2-[3-(6-morpholin-4-yl-8-oxa-3,5,10-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-4-yl)phenoxy]phenyl]acetamide |
| InChI | InChI=1S/C27H25N7O4/c28-15-22(35)31-20-14-17(29)6-7-21(20)37-18-4-1-3-16(13-18)25-32-23-19-5-2-8-30-27(19)38-24(23)26(33-25)34-9-11-36-12-10-34/h1-8,13-14H,9-12,15,28-29H2,(H,31,35) |
| InChIKey | MTALGWVUOBSKIC-UHFFFAOYSA-N |
| SMILES | C1COCCN1C2=NC(=NC3=C2OC4=C3C=CC=N4)C5=CC(=CC=C5)OC6=C(C=C(C=C6)N)NC(=O)CN |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
