RF9 hydrochloride

• CAT Number: I045882
• Molecular Formula: C26H39ClN6O3
• Molecular Weight: 519.08
• Purity: ≥95%
• Synonyms: N-[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]adamantane-1-carboxamide;hydrochloride
• IUPAC Name: N-[(2S)-1-[(1-amino-1-oxo-3-phenylpropan-2-yl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]adamantane-1-carboxamide;hydrochloride
• InChI: InChI=1S/C26H38N6O3.ClH/c27-22(33)21(12-16-5-2-1-3-6-16)31-23(34)20(7-4-8-30-25(28)29)32-24(35)26-13-17-9-18(14-26)11-19(10-17)15-26;/h1-3,5-6,17-21H,4,7-15H2,(H2,27,33)(H,31,34)(H,32,35)(H4,28,29,30);1H/t17?,18?,19?,20-,21?,26?;/m0./s1
• InChIKey: SPYLIOBZVVTVOO-ARJXCTANSA-N
• SMILES: C1C2CC3CC1CC(C2)(C3)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NC(CC4=CC=CC=C4)C(=O)N.Cl

RF9 hydrochloride（Cat No.:I045882）is a selective and potent antagonist of neuropeptide FF (NPFF) receptors, NPFF1 and NPFF2, which regulate pain modulation, opioid tolerance, and neuroendocrine functions. By blocking NPFF signaling, RF9 enhances opioid analgesia while reducing the development of tolerance and dependence, making it an important tool in pain and addiction research. Additionally, it modulates hypothalamic-pituitary-gonadal axis activity, aiding studies of reproductive endocrinology. Supplied as a hydrochloride salt for solubility and stability, RF9 is widely applied in neuropharmacology to probe NPFF-mediated pathways and therapeutic strategies.