For research use only. Not for therapeutic Use.
Reveromycin A（Cat No.:M110683）is a natural polyketide antibiotic isolated from Streptomyces species, notable for its unique spiroacetal structure and selective biological activities. It exhibits strong inhibitory effects on osteoclast activity, making it a promising lead for bone-related diseases such as osteoporosis and cancer-induced bone metastasis. Reveromycin A also shows antifungal and anticancer properties by disrupting cellular processes linked to apoptosis and differentiation. Its ability to target osteoclasts without significantly affecting osteoblasts highlights its therapeutic potential, while also serving as a valuable tool in bone metabolism research.
| CAS Number | 134615-37-5 |
| Synonyms | (2E,4S,5S,6E,8E)-10-[(2S,3R,6S,8R,9S)-3-butyl-2-[(1E,3E)-4-carboxy-3-methylbuta-1,3-dienyl]-3-(3-carboxypropanoyloxy)-9-methyl-1,7-dioxaspiro[5.5]undecan-8-yl]-5-hydroxy-4,8-dimethyldeca-2,6,8-trienoic acid |
| Molecular Formula | C36H52O11 |
| Purity | ≥95% |
| IUPAC Name | (2E,4S,5S,6E,8E)-10-[(2S,3R,6S,8R,9S)-3-butyl-2-[(1E,3E)-4-carboxy-3-methylbuta-1,3-dienyl]-3-(3-carboxypropanoyloxy)-9-methyl-1,7-dioxaspiro[5.5]undecan-8-yl]-5-hydroxy-4,8-dimethyldeca-2,6,8-trienoic acid |
| InChI | InChI=1S/C36H52O11/c1-6-7-19-35(47-34(44)17-16-32(40)41)21-22-36(46-30(35)14-10-25(3)23-33(42)43)20-18-27(5)29(45-36)13-9-24(2)8-12-28(37)26(4)11-15-31(38)39/h8-12,14-15,23,26-30,37H,6-7,13,16-22H2,1-5H3,(H,38,39)(H,40,41)(H,42,43)/b12-8+,14-10+,15-11+,24-9+,25-23+/t26-,27-,28-,29+,30-,35+,36-/m0/s1 |
| InChIKey | ZESGNAJSBDILTB-OXVOKJAASA-N |
| SMILES | CCCC[C@]1(CC[C@]2(CC[C@@H]([C@H](O2)C/C=C(\C)/C=C/[C@@H]([C@@H](C)/C=C/C(=O)O)O)C)O[C@H]1/C=C/C(=C/C(=O)O)/C)OC(=O)CCC(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
