Retro-2

• CAT Number: I045524
• CAS Number: 1201652-50-7
• Molecular Formula: C19H16N2OS
• Molecular Weight: 320.41
• Purity: ≥95%

Retro-2 (Cat No.: I045524) is a small-molecule inhibitor known for blocking retrograde transport within cells, specifically targeting the Golgi-to-endoplasmic reticulum trafficking pathway. It prevents toxins such as ricin and Shiga toxin, as well as certain pathogens, from hijacking host retrograde transport systems. By interfering with vesicle trafficking, Retro-2 shows promise as an antiviral and antibacterial agent. Its potential therapeutic applications extend to infectious diseases, including viral infections and bacterial toxin exposures, positioning it as a valuable experimental tool in biomedical research.

Reference

[1]. Bahne Stechmann, et al. Inhibition of retrograde transport protects mice from lethal ricin challenge. Cell. 2010 Apr 16;141(2):231-42.
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[2]. Valérie Nicolas, et al. Small Trafficking Inhibitor Retro-2 Disrupts the Microtubule-Dependent Trafficking of Autophagic Vacuoles. Front Cell Dev Biol. 2020 Jun 18;8:464.
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[3]. Olena Shtanko, et al. Retro-2 and its dihydroquinazolinone derivatives inhibit filovirus infection. Antiviral Res. 2018 Jan;149:154-163.
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