For research use only. Not for therapeutic Use.
RET-IN-7（Cat No.:I045219）is a potent, selective inhibitor of the RET (rearranged during transfection) receptor tyrosine kinase, which regulates cell growth, differentiation, and survival. Aberrant RET activation, through mutations, fusions, or overexpression, drives various cancers, including medullary thyroid carcinoma and non-small cell lung cancer. By blocking RET phosphorylation and downstream MAPK/PI3K signaling, RET-IN-7 suppresses tumor proliferation and survival. It is a valuable research tool for studying RET-driven oncogenesis and targeted therapy development. RET-IN-7 holds therapeutic potential for precision oncology in RET-altered malignancies, including treatment-resistant and metastatic disease.
| CAS Number | 2763386-05-4 |
| Synonyms | methyl N-[4-[4-amino-5-(5-amino-4-chloro-2-fluorophenyl)pyrrolo[2,3-d]pyrimidin-7-yl]-1-bicyclo[2.2.2]octanyl]carbamate |
| Molecular Formula | C22H24ClFN6O2 |
| Purity | ≥95% |
| IUPAC Name | methyl N-[4-[4-amino-5-(5-amino-4-chloro-2-fluorophenyl)pyrrolo[2,3-d]pyrimidin-7-yl]-1-bicyclo[2.2.2]octanyl]carbamate |
| InChI | InChI=1S/C22H24ClFN6O2/c1-32-20(31)29-21-2-5-22(6-3-21,7-4-21)30-10-13(17-18(26)27-11-28-19(17)30)12-8-16(25)14(23)9-15(12)24/h8-11H,2-7,25H2,1H3,(H,29,31)(H2,26,27,28) |
| InChIKey | FJTQBVRKZLEDPK-UHFFFAOYSA-N |
| SMILES | COC(=O)NC12CCC(CC1)(CC2)N3C=C(C4=C(N=CN=C43)N)C5=CC(=C(C=C5F)Cl)N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
